VIVAnews - Alan Aderem, Director of BioMed, Seattle and Rino Rappuoli, Global Head of Vaccines Research for Novartis Vaccines and Diagonstics, reviewed the latest progress in vaccine development in a scientific journal, Nature.
They write, it is estimated, by 2020, a vaccine for malaria, tuberculosis (TB) and HIV / AIDS is found. In the journal that they also discussed the new devices include systems biology and structure-based design of antigens that can provide a better understanding of the mechanism of protection.
This device will give clues leading to the rational development of vaccines to alleviate the patient's most terrible diseases in the world.
According Aderem, a pioneer in the field of systems biology, new concepts and technological advances indicate that the vaccine for three diseases terdahsyat it will be developed within the next 10 years.
"The success will greatly depend on our ability to approach biological systems to analyze data generated during testing of evidence," said Aderem, like diktutip from MedIndia, May 28, 2011.
Aderem says, success will also provide new insights such as identifying the relationship between protection or signs of immunogenicity and the acceleration of large-scale clinical trials. Also, added Aderem, new regulatory approaches and innovative clinic will also accelerate the discovery of vaccines that are needed.
In his report, Aderem and Rappuoli also reviews the advantages and disadvantages of systems biology approach, with the major advantages of this approach is the ability to capture and integrate biological data in a very large number that appears to visualize the nature of which is not shown by the parts individually and unpredictable if you only use every single part.
"The advantage of biological systems is its ability to predict the behavior of entire biological systems," said Aderem. "From there, we can optimize vaccine candidates and predict whether the drug or vaccine candidates able to work before the drug was taken to a large-scale clinical trials are very expensive," he said.
Biological systems can also be used to accelerate clinical trials usually last long.
Aderem and Rappuoli predicts that in a trial vaccine for malaria, TB and HIV / AIDS, only one hypothesis successfully tested every eight years in the past three decades. "We can not continue to use this approach if we want to get results in the period immediately," said Aderem.
With this new method, said Aderem, we can accelerate development by conducting clinical trials of more efficacious and to improve the design using a systems biology approach to test several hypotheses in parallel and have an adaptive design to extend the results will prove most promising.• VIVAnews
They write, it is estimated, by 2020, a vaccine for malaria, tuberculosis (TB) and HIV / AIDS is found. In the journal that they also discussed the new devices include systems biology and structure-based design of antigens that can provide a better understanding of the mechanism of protection.
This device will give clues leading to the rational development of vaccines to alleviate the patient's most terrible diseases in the world.
According Aderem, a pioneer in the field of systems biology, new concepts and technological advances indicate that the vaccine for three diseases terdahsyat it will be developed within the next 10 years.
"The success will greatly depend on our ability to approach biological systems to analyze data generated during testing of evidence," said Aderem, like diktutip from MedIndia, May 28, 2011.
Aderem says, success will also provide new insights such as identifying the relationship between protection or signs of immunogenicity and the acceleration of large-scale clinical trials. Also, added Aderem, new regulatory approaches and innovative clinic will also accelerate the discovery of vaccines that are needed.
In his report, Aderem and Rappuoli also reviews the advantages and disadvantages of systems biology approach, with the major advantages of this approach is the ability to capture and integrate biological data in a very large number that appears to visualize the nature of which is not shown by the parts individually and unpredictable if you only use every single part.
"The advantage of biological systems is its ability to predict the behavior of entire biological systems," said Aderem. "From there, we can optimize vaccine candidates and predict whether the drug or vaccine candidates able to work before the drug was taken to a large-scale clinical trials are very expensive," he said.
Biological systems can also be used to accelerate clinical trials usually last long.
Aderem and Rappuoli predicts that in a trial vaccine for malaria, TB and HIV / AIDS, only one hypothesis successfully tested every eight years in the past three decades. "We can not continue to use this approach if we want to get results in the period immediately," said Aderem.
With this new method, said Aderem, we can accelerate development by conducting clinical trials of more efficacious and to improve the design using a systems biology approach to test several hypotheses in parallel and have an adaptive design to extend the results will prove most promising.• VIVAnews
